Dr. MAL

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Dr.MAL

1. What is PDT?

What is PDT Treatment for Acne?

PDT refers to a treatment which applies a photosensitizer on skin that selectively permeates into sebaceous glands and pores, or which irradiates a certain wavelength or laser on skin in order to selectively destroy acne bacteria.

01

When a pore with inflammation absorbs the Dr.MAL(Methyl ALA), it is transformed into Pplx.

02

Photodynamic Therapy refers to the process of irradiating the light energy of a certain wavelength, followed by the application of a photosensitizer, which selectively permeates into the sebaceous glands and pores.

03

As the light of a certain wavelength is irradiated, it destroys acne bacteria and sebaceous glands resulting in the reduced inflammation.

2. Key Ingredients
Methyl ALA 10.8%

MAL is a photosensitizer formed by adding Methyl to the commonly used ALA for enhanced stability



Panax Ginseng Callus Culture Extract

• Effective for strengthening damaged skin barriers
• Protects the skin from the UV lights during irradiation



3. Why Dr.MAL?

The great effect of mal pdt

Easily applied as a gel, Methy-ALA shows the same effect as IPL by just irradiating the LED


The Korean society for acne research, 2011:41.
Acne treatment by Methyl aminolevulinate photodynamic therapy with Red light vs. Intense pulsed light.
Jong soo Hong, MD, Jae Yoon Jung, MD, Ji Young Yoon, BS, Dae Hun Suh, MD, PhD

Reduced pain during mal pdt

Methy-ALA (MAL) being oil-soluble shows a greater selective absorption rate for pathologic cells than ALA, thereby causing less damage of healthy cells, resulting in less pain during irradiation

HIGH SATISFACTION level

MAL-PDT shows a significantly higher effect in treating inflammatory acne than ALA-PDT



Median reduction in numbers of inflammatory lesion counts from baseline.

J Am Acad Dermatol, 2006 Apr:54(4), 647-651. Photo Dynamic Therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate, Wiegell SR, Wulf HC
J Clin Aesthet Dermatol. 2009 February; 2(2):44-47. Therapeutic and aesthetic uses of Photo Dynamic Therapy part five of a five-part series ALA-PDT and MAL-PDT, What Makes Them Different, Michael H. Gold. MD

improved safety

Dr.MAL minimizes PDT side effects by means of using safe photosensitizer with optimal concentration level suited for acne-prone skin-types during PDT



British Journal of Dermatology 2010 163, pp1064-1071. Investigation of optimal aminolevulinic acid concentration applied in topical aminolaevulinic acid–photodynamic therapy for treatment of moderate to severe acne: a pilot study in Chinese subjects R. Yin, F. Hao, J. Deng, X.C. Yang and H. Yan

Post Dr.MAL Cleanser included

1. First in South Korea to use ALA neutralizer which leads to minimization of side effects caused by remaining ALA on skin
2. By destroying the remaining ALA, one can resume daily activities simply with application of UV protection





Korean J Lab Med 2002; 22(3): 163-168
European Journal of Pharmaceutical Sciences, 1999 Jan;7(2):87-91. Stability of 5-aminolevulinic acid in aqueous solution. B. Elfssona, I. Wallina, S. Eksborga, K. Rudaeusa, A.M. Rosb, H. Ehrssona

4. Procedure Guideline

STEP 01 Preparation

1. Cleanse the Skin

Peeling helps the absorption of Dr. MAL
2. Extract Acne

Extract comedonal and inflammatory acne first

STEP 02 Photodynamic Therapy (PDT)

3. Apply Dr. MAL

Apply in the area of acne followed by rest of the face
4. Incubation 20~25 min

MAL gets absorbed by skin, binding with inflammatory and sebaceous cells. Block the light by covering the entire face with a wrap, followed by a dark towel
5. Remove solution

Remove the remaining MAL and cleanse the area completely using a cleansing sponge
6. LED Irradiation 15~20 min (RED Light 630nm)

Occurrence of PDT reaction. The absorbed Dr.MAL solution meets the LED Light source

STEP 03 Finishing

7. Apply Cleanser

Use 3~5 pumps and gently rub for 3~5 minutes to prevent tanning which could occur after PDT reaction
8. Remove with Cleanser

Cleanse the area using a cleansing sponge
9. Apply skin relief

For Cooling & Skin Regeneration
10. UV Prevention

Do not skip this mandatory step
5. Treatment Cycles

Total 3~5 treatments
1 treatment every 2 weeks



6. Clinical Trial

5 TREATMENTS BIWEEKLY



7. Packages



Dr.MAL 1.1 mL x 9 vial
POST Dr.MAL Cleanser 100 mL